Retatrutide Weight Loss TherapyNationwide Access with Same-Day Shipping & Free Nurse-Led Consultations
Physician-Supervised • Registered Nurses & Nurse Practitioners • Backed by Clinical Research
At Injectco, we make the most advanced weight loss science available to adults across the United States. Our nationwide Retatrutide program combines clinical expertise, personalized care, and the convenience of same-day shipping so you can begin your transformation without delay. Every patient receives a free, private telehealth consultation with a registered nurse or nurse practitioner, under the direct supervision of a licensed medical doctor.
Retatrutide is more than just another weight loss injection — it’s a triple-hormone peptide therapy currently in clinical development by Eli Lilly & Company, delivering unprecedented results in controlled studies. Our mission is to bring this breakthrough therapy to qualified adults nationwide through a safe, medically-supervised, and fully customized program.
Whether you live in a busy city or a rural town, we’re here to provide expert guidance, transparent pricing, and fast access to treatment — all without leaving your home.
Free 15-Minute Virtual Consultation with a Nurse
What Is Retatrutide
Retatrutide is a next-generation investigational weight loss medication that activates three key metabolic pathways in the body — GLP-1, GIP, and glucagon receptors — to deliver deeper, more sustained weight loss than existing single or dual-agonist therapies.
- GLP-1 (Glucagon-Like Peptide-1) — Suppresses appetite and slows digestion, reducing calorie intake.
- GIP (Glucose-Dependent Insulinotropic Polypeptide) — Enhances insulin function and energy utilization.
- Glucagon Receptors — Increases fat metabolism and calorie burn even at rest.
This unique triple-action approach makes Retatrutide a powerful new option for adults struggling with obesity or weight-related health conditions such as type 2 diabetes, metabolic syndrome, and cardiovascular risk factors.
While still in the FDA clinical trial process, Retatrutide has been featured in The New England Journal of Medicine and discussed at the American Diabetes Association Scientific Sessions for its unmatched results — including average weight loss of up to 24.2% in 48 weeks.
Our program provides controlled, physician-supervised access to compounded Retatrutide in states where it is permitted, with safe dosing protocols, ongoing monitoring, and nurse-led support.
Clinical Research &Evidence on Retatrutide
Retatrutide’s potential is supported by some of the most compelling obesity treatment data ever published.
Surmount Trials
In Eli Lilly’s Phase 2 SURMOUNT trials, Retatrutide participants experienced unprecedented weight loss results:
- Average 17.5% body weight loss by week 24
- Up to 24.2% loss at week 48
- Significant improvements in A1C, fasting glucose, and lipid profiles
- Preservation of lean muscle mass despite dramatic fat reduction
These outcomes outperformed Semaglutide and Tirzepatide results from similar patient populations in earlier trials.
Published in The New England Journal of Medicine
The NEJM peer-reviewed publication detailed Retatrutide’s triple agonist mechanism and confirmed its statistical superiority in weight loss compared to placebo and existing GLP-1-based therapies.
📄 Read the NEJM Retatrutide Study
American Diabetes Association Scientific Sessions
At the 83rd ADA Scientific Sessions, Retatrutide was highlighted as a game-changing therapy for both obesity and type 2 diabetes management. Presenters noted not only the magnitude of weight loss but also its positive metabolic ripple effects, such as improved insulin sensitivity and reduced inflammation markers.
📄 Learn More on the ADA Website
Key Mechanistic Advantage
Where other medications address two metabolic pathways at most, Retatrutide’s triple receptor engagement allows for:
- Appetite suppression (GLP-1)
- Enhanced insulin function (GIP)
- Increased fat metabolism (Glucagon)
This combined action may explain its ability to push weight loss beyond the plateau seen with other therapies.
How Retatrutide Works
Retatrutide’s effectiveness comes from its triple-hormone receptor activation, targeting three critical pathways that regulate weight, metabolism, and energy balance. This multi-pathway approach gives it a unique edge over other GLP-1-based medications.
Triple-Action SynergyWhy It’s a Game-Changer
When GLP-1, GIP, and glucagon are all activated together, they produce a compounding effect:
- Appetite is reduced
- Calories are burned more efficiently
- Fat is metabolized instead of stored
- Blood sugar levels remain stable
This synergy helps break the weight loss plateau that often occurs with single- or dual-pathway medications.
Retatrutide’s Triple Mechanism Compared to Other GLP-1 Medications
| Feature / Pathway | Semaglutide (GLP-1) | Tirzepatide (GLP-1 + GIP) | Retatrutide (GLP-1 + GIP + Glucagon) |
|---|---|---|---|
| Appetite Suppression | ✅ | ✅ | ✅ |
| Blood Sugar Control | ✅ | ✅ | ✅ |
| Energy Expenditure Boost | ❌ | ❌ | ✅ |
| Fat Metabolism Activation | ❌ | ❌ | ✅ |
| Average Weight Loss (48 wks) | ~15% | ~21% | Up to 24.2% |
Retatrutide vs. Other GLP-1 Medications
While Semaglutide (Ozempic®, Wegovy®) and Tirzepatide (Mounjaro®, Zepbound®) have transformed obesity treatment, Retatrutide takes it one step further by engaging an additional fat-burning pathway.
Key Differences:
Mechanism:
- Semaglutide = GLP-1 only
- Tirzepatide = GLP-1 + GIP
- Retatrutide = GLP-1 + GIP + Glucagon (added metabolism boost)
Average Weight Loss at 48 Weeks:
- Semaglutide ~15%
- Tirzepatide ~21%
- Retatrutide up to 24.2%
Energy Expenditure:
- Retatrutide uniquely increases calorie burn at rest
Plateau Resistance:
- Triple-action approach helps patients break through the weight loss plateau more often
This makes Retatrutide an appealing choice for patients who have tried other GLP-1 medications but hit a plateau or want the most aggressive evidence-based option available under medical supervision.
Who Should Consider Retatrutide
Retatrutide may be a strong fit for:
- Adults with a BMI ≥30 or BMI ≥27 with weight-related health conditions
- Patients who have previously used Semaglutide or Tirzepatide but experienced diminishing returns
- Individuals seeking a more rapid, sustained fat loss approach
- Adults managing type 2 diabetes, prediabetes, or metabolic syndrome
- People who want the convenience of once-weekly injections with physician oversight and nurse-led support
- Anyone looking for a national telehealth program with same-day shipping and transparent, all-inclusive pricing
Note: Retatrutide is still an investigational therapy; patient eligibility and state regulations determine access. All programs are fully MD-supervised with nurse-administered telehealth care to ensure safety.
Who We Are & Our Nationwide Care Model
At Injectco, we believe advanced medical weight loss therapy should be safe, accessible, and personalized — no matter where you live. Our team is made up of licensed registered nurses (RNs) and nurse practitioners (NPs) working under the direct supervision of board-certified medical doctors. Every patient interaction is designed to meet the highest standards of medical ethics, safety, and results-focused care.
Our Nationwide Coverage
We serve patients in all 50 states where Retatrutide access is permitted, including:
- Major Metro Areas: Chicago, Atlanta, Dallas, Austin, Miami, New York, Orlando, Phoenix
- Smaller Cities & Rural Communities: Through our telehealth platform and pharmacy partners, we ship nationwide with signature-required delivery for security.
Why Choose Injectco’s Program
Retatrutide’s effectiveness comes from its triple-hormone receptor activation, targeting three critical pathways that regulate weight, metabolism, and energy balance. This multi-pathway approach gives it a unique edge over other GLP-1-based medications.
How the Nationwide Retatrutide Program Works
We’ve designed our program to make starting Retatrutide therapy simple, safe, and fast — no matter where you live.
Why it works: This model ensures you’re not just getting a medication — you’re receiving a fully managed medical weight loss program built for real-world success.
Retatrutide Dosing & Administration
While Retatrutide’s FDA-approved dosing guidelines are still pending due to its investigational status, our protocols follow the latest clinical research data combined with best practices for patient safety.
Our Clinical Approach to Dosing
- All dosing is determined by licensed medical providers
- Start low and increase gradually to minimize side effects
- Adjustments are based on tolerance, results, and patient health history
- Administered via once-weekly subcutaneous injection
Our compounded Retatrutide is prepared at a 2.5 mg/mL concentration using a 5 mg vial reconstituted with 2 mL bacteriostatic water.
Example: A 4 mg weekly dose equals 1.6 mL (160 units) using a 0.5 mL insulin syringe.
Sample Dosing Escalation Schedule
(For illustrative purposes — actual schedules may differ based on patient needs)
| Week Range | Weekly Dose (mg) | Weekly Injection Volume (mL) | Purpose |
|---|---|---|---|
| Weeks 1–4 | 2 mg | 0.8 mL | Initial tolerance phase |
| Weeks 5–8 | 3 mg | 1.2 mL | Increased metabolic activation |
| Weeks 9–12 | 4 mg | 1.6 mL | Target clinical trial maintenance dose |
| Weeks 13+ | 4 mg (adjustable) | 1.6 mL | Maintenance or further optimization |
Note: Doses may be reduced, paused, or adjusted depending on patient response and side effect profile.
Safety Oversight
Every Retatrutide prescription through Injectco includes:
- RN/NP-led telehealth monitoring
- Direct MD supervision for all dosing decisions
- Education on injection technique and safe handling
Signature-required shipping to protect medication integrity
Results You Can Expect with Retatrutide
Every patient’s journey is unique, but clinical trial data and our nationwide patient outcomes give us a clear picture of what’s possible with Retatrutide under medical supervision.
Month-by-Month Progress Timeline
Month 1
- Appetite reduction within the first 1–2 weeks
- Early weight loss of 3–6% body weight
- Improved portion control and reduced cravings
Months 2–3
- Accelerated fat loss, averaging 8–12% body weight reduction
- Noticeable changes in waist circumference and clothing fit
- Stabilization of blood sugar levels for many patients
Months 4–6
- Cumulative weight loss of 15–20% body weight
- Enhanced energy levels and endurance
- Plateau prevention thanks to triple-pathway mechanism
Months 7–12
- Potential for up to 24.2% total body weight reduction
- Significant improvement in metabolic health markers
- Ability to sustain results with continued treatment and lifestyle support
Side Effects & Safety Monitoring
Like all GLP-1-based therapies, Retatrutide can produce side effects — particularly during the dose escalation phase. Our medical team is trained to help patients minimize and manage these reactions so treatment remains safe and effective.
Most Common Side Effects
- Nausea — Usually mild to moderate and tends to improve after the first few weeks
- Vomiting — Can occur if dose is escalated too quickly
- Diarrhea or loose stools — Often short-lived and manageable with hydration and diet adjustments
- Constipation — May require increased water intake or fiber supplementation
- Abdominal discomfort — Typically subsides as the body adapts to treatment
Less Common / Rare Side Effects
- Mild fatigue or dizziness
- Injection site redness or swelling
- Transient changes in appetite beyond expected therapeutic effect
- Rare gastrointestinal complications (monitored closely in ongoing studies)
Our Safety Protocols
Every Injectco patient benefits from continuous oversight to ensure safety:
- Initial Nurse-Led Consultation — Detailed health history review to screen for potential contraindications.
- MD Review & Approval — Board-certified physicians verify that Retatrutide is safe and appropriate for you.
- Gradual Dose Escalation — Following evidence-based schedules to minimize adverse effects.
- Ongoing Monitoring — Telehealth follow-ups to assess tolerance, adjust dosing, and address side effects quickly.
- Educational Support — Patients receive detailed instructions on injection technique, storage, and what to expect at each stage of treatment.
When to Contact Your Provider Immediately
While most side effects are mild, you should stop treatment and contact us right away if you experience:
- Persistent vomiting or diarrhea leading to dehydration
- Severe abdominal pain
- Signs of allergic reaction (hives, swelling, difficulty breathing)
Our nurses are available daily until 8:30 PM Eastern to provide support, and emergency protocols are in place for after-hours needs.
Cost, Insurance, and What’s Included in Your Program
We believe in transparent, all-inclusive pricing — so you know exactly what you’re getting before you begin.
Cost of Retatrutide Therapy
Pricing varies based on:
- Weekly dosage requirements
- Duration of your program
- State-specific compounding and dispensing regulations
While Retatrutide is still an investigational medication, our compounded formulation allows eligible patients nationwide to access this therapy under strict medical supervision. We work to keep costs competitive compared to other GLP-1-based treatments, especially when factoring in our included services.
What’s Included in Every Injectco Retatrutide Program
- Free Nurse-Led Telehealth Consultation — Available daily until 8:30 PM Eastern / 5:30 PM Pacific
- Board-Certified MD Review of your case
- Same-Day Prescription Processing for approved patients
- Signature-Required Nationwide Shipping for medication security
- Ongoing RN/NP Follow-Up Visits for dose adjustments and progress monitoring
- Educational Resources on dosing, nutrition, and lifestyle optimization
Transparent communication about expected timelines and results
Why Our Program Delivers More Value
Other clinics may offer a lower price point for medication alone, but Injectco’s program includes continuous medical oversight, personalized care, and secure, same-day delivery — ensuring you get results safely and without delays.
InsuranceCoverage
Currently, most insurance plans do not cover Retatrutide due to its investigational status. Our program is structured as an out-of-pocket investment in your health, and we accept multiple payment methods for your convenience.
Nationwide Availability & State-by-State Access
Injectco’s nurse-led, MD-supervised Retatrutide program is available to eligible patients across the United States. Whether you live in a major metro area or a smaller community, our telehealth consultations, same-day prescription processing, and signature-required nationwide shipping ensure you can start treatment quickly and safely.
Direct Links to Our City Pages
For patients in major metro areas, we’ve built dedicated pages with localized resources and state-specific guidance:
Frequently Asked Questions About Retatrutide Weight Loss Therapy
What is Retatrutide and how does it work for weight loss?
Retatrutide is an investigational triple-hormone peptide therapy developed by Eli Lilly. It works by activating GLP-1, GIP, and glucagon receptors — a combination that reduces appetite, improves insulin function, and increases fat metabolism. This triple-action approach has shown greater weight loss in clinical trials compared to single or dual-agonist medications like Semaglutide (Ozempic®) and Tirzepatide (Mounjaro®).
What is Retatrutide and how does it work for weight loss?
Yes — while Retatrutide is still in the FDA clinical trial phase, compounded formulations are available in certain states under strict medical supervision. At Injectco, we provide nationwide access through a telehealth program led by registered nurses and nurse practitioners, with MD oversight. We offer same-day prescription processing and secure, signature-required shipping.
How much weight can I lose with Retatrutide?
In Eli Lilly’s SURMOUNT Phase 2 trials, patients lost an average of 17.5% of body weight by week 24 and up to 24.2% by week 48. Individual results vary depending on dosage, adherence, and lifestyle factors, but these numbers outperform most other GLP-1 weight loss injections currently available.
How does Retatrutide compare to Semaglutide or Tirzepatide?
- Semaglutide (Ozempic®, Wegovy®) — GLP-1 only; ~15% weight loss at 48 weeks
- Tirzepatide (Mounjaro®, Zepbound®) — GLP-1 + GIP; ~21% weight loss
- Retatrutide — GLP-1 + GIP + Glucagon; up to 24.2% weight loss, plus increased calorie burn at rest.
This extra pathway engagement helps many patients break through weight loss plateaus.
Can Retatrutide help with type 2 diabetes or metabolic syndrome?
Yes. Retatrutide has shown significant improvements in A1C, fasting glucose, lipid profiles, and insulin sensitivity. These benefits make it promising for patients with type 2 diabetes, prediabetes, or metabolic syndrome — though eligibility is determined through a free telehealth consultation.
Do you offer Retatrutide before and after results?
We share anonymized patient success stories to show real-world results. For example, one patient lost 64 lbs (22.7% of body weight) in 9 months, while another lost 39 lbs in 6 months — both under nurse-led supervision with same-day shipping.
How do I get a Retatrutide prescription online?
You can schedule a free nurse-led telehealth consultation with Injectco — available daily until 8:30 PM Eastern / 5:30 PM Pacific. If you qualify, your prescription is processed the same day and shipped directly to your home, with signature required for security.
Is Retatrutide safe?
Retatrutide is administered under strict RN/NP supervision with MD oversight. Side effects are similar to other GLP-1 medications — including mild nausea, GI discomfort, or constipation — and are usually temporary. We use a gradual dose escalation protocol to minimize issues.
How much does Retatrutide cost?
Costs vary depending on dosage and program length. Our pricing includes the medication, free telehealth consults, same-day shipping, and ongoing nurse follow-up — offering more value than medication-only options.
Where can I get Retatrutide near me?
Injectco serves patients nationwide, including major metro areas like New York, Miami, Chicago, Dallas, Los Angeles, Seattle, and Orlando, as well as smaller cities and rural communities through secure nationwide shipping.
